Evidence-based nootropic and cognitive supplement reviews. See our Nootropics Guide.
Nootropics
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200mg caffeine + 200mg L-theanine significantly outperforms either alone on attention and memory in 8+ RCTs, while eliminating caffeine's jitteriness. We ...
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Lion's mane has one good RCT in older adults with MCI showing cognitive improvement. For healthy adults, human evidence is lacking. We review the NGF mechanism ...
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Does ashwagandha lower cortisol? Three double-blind RCTs confirm KSM-66 reduces cortisol by 23-32% in stressed adults. We explain how it works and why form ...
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Rhodiola rosea has +173% search growth in 2026. We review 3 placebo-controlled trials including a head-to-head comparison with sertraline, plus exactly what ...
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Methylene blue is surging +309% in 2026 searches. We review the actual evidence for cognitive benefits, the serious safety considerations including MAOI ...
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Methylene blue searches grew 309% in 2026. We review the fMRI human evidence, the serious serotonin syndrome drug interactions, the regulatory status, and why ...
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Saffron has more clinical evidence for mood support than almost any other natural compound. We review 20+ RCTs, compare standardised extracts (Affron vs ...
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Rhodiola rosea searches grew 173% in 2026. We review 36 human clinical trials on stress, fatigue, and cognitive performance — and compare it to ashwagandha for ...
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Lion's mane is the most-searched functional mushroom of 2026. We break down the NGF evidence, human trials on memory and mood, dosing, and the best products.
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Alpha Brain has more clinical evidence than almost any nootropic on the market. We break down both trials, analyze each ingredient, and give you an honest ...
